The following three types of drugs have the renal toxicity

Besides antibiotics, there are many other drugs owning renal toxicity, gradually damaging renal function.
1. Analgesics: ibuprofen, aspirin.
The drug has varying degrees of kidney damage. The drug also leads to a form of analgesic nephropathy, a chronic interstitial nephritis caused by long-term use of nonsteroidal anti-inflammatory drugs. Small doses would cause less damage to kidney function and can damage the kidneys if used for long or overdose.
Patients with nephropathy should minimize the dose and reduce the damage to the kidneys.
The following three types of drugs have the renal toxicity

2. Diuretics. Diuretics can use different mechanisms to excrete excess sodium through the kidneys, thereby achieving diuresis and maintaining sodium balance. But recent studies have shown that although diuretics can increase the amount of urine output, it can increase creatinine later in life.
In addition, thiazide diuretics can also raise blood sugar.
3. Calcium neuraminidase inhibitor (CNI)
Calcineurin inhibitors promote the release of vasoconstrictor substances, leading to ischemic injury.
However, the contraction of the small arteries can lead to the renal toxicity of the functional calcineurin, while the chronic renal injury is irreversible.

Article URL：http://www.kidneyhospital.org/faq/3364.html

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