The clinical research for serum creatinine

Most clinical laboratories now align their creatinine measurements against a new standardized isotope dilution mass spectrometry (IDMS) method to measure serum creatinine.
The IDMS method would result in a comparative overestimation of the corresponding calculated GFR in some patients with normal renal function. A few medicines are dosed even in normal renal function on that derived GFR. The dose, unless further modified, could now be higher than desired, potentially causing increased drug-related toxicity.

A concern as of late 2010 relates to the adoption of a new analytical methodology, and a possible impact this may have in clinical medicine.
A 2009 Japanese study found a lower serum creatinine level to be associated with an increased risk for the development of type 2 diabetes in Japanese men.
Article URL ：http://www.tcmkidneydisease.com/faq/877.html

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