How does high uric acid damage the kidney?

In normal purine diet, male > 420umol/L, women > 360umol/L, is hyperuricemia. Hyperuricemia is closely related to hypertension, metabolic syndrome, kidney disease, diabetes and so on. So how does hyperuricemia damage the kidneys?
Direct damage
The uric acid level is too high, which exceeds the normal excretion capacity of the kidney, which results in a large amount of uric acid deposition in the renal tubule and renal interstitium, which causes the renal material damage.
How does high uric acid damage the kidney?
In addition, uric acid stones formed by hyperuricemia can also induce obstruction and obstruction related complications, and direct injury to the kidneys.
Indirect damage
High uric acid levels can increase blood viscosity and cause abnormal function of endothelial cells, which can lead to hypertension and vascular disease.
Hyperuricemia can directly or indirectly activate the RAS system, reduce the function of the renal tubular endothelial cells, and eventually develop terminal lesions such as kidney failure.
High uric acid associated with hyperglycemia, obesity, dyslipidemia, hypertension and insulin resistance can aggravate renal burden and CKD progression.
Article URL : http://www.sjzhospital.com/faq/4048.html

评论

发表评论

此博客中的热门博文

Normal Conditions of Bubbles in Urine

图片
Here are some benign conditions that can cause urine to bubble. Bubbles during Rapid Urination Dehydration can cause people to urinate rapidly. If bubbles in urine are due to dehydration, increasing the level of hydration can help reverse this finding. Bubbles due to Mild Dehydration Mild dehydration can result in bubbles in urine. This occurs because mild dehydration causes the urine to concentrate and highly concentrated urine tends to bubble. Because people with diabetes are at high risk for dehydration, they may experience bubbles in their urine more often than those who do not have diabetes. Bubbles during Pregnancy During pregnancy some women experience kidney enlargement. This enlargement can result in urine that bubbles. When the amount of amino acids exceeds the renal tubules ability to absorb the acids, protein can escape into the urine. Protein in the urine can cause the urine to bubble. Abnormal Conditions of Bubbles in Urine There are times when bub
阅读全文

The best mix of light meals for kidney patients

图片
The light diet should be diversified in food, and in order to ensure the rationality of nutritious eating in a weight-reducing diet, do not overlook these   five   types of food! 1 fruit Fruit is one of the important sources of vitamin supplements in the daily diet, and it is extremely important for regulating metabolism in the body and can promote our metabolism. 2 vegetables Vegetables also belong to low-carbohydrate foods, and contain nutrient-rich antioxidants, vitamins, minerals and cellulose, which are important factors in improving immunity and are important safeguards for the normal digestion of the gastrointestinal tract. 3 soy products Soybean products contain protein that is comparable to meat, but the calories are very low. At the same time, most soy products contain a lot of fiber, which is positive for the decomposition of fat and the suppression of fat deposits. 4 lean meat Lean, rich in protein, is enough to supply our body with the protein it needs e
阅读全文

What is the definition for the light diet?

图片
A truly light diet is a diet that tends to be light and light on the premise of balanced diet and reasonable nutrition. One of the criteria for a light diet is: less oil, less sugar, less salt, heavy taste, and proper cooking. 1 Choose the right cooking method If we want to eat healthy, we have better choose steamed, boiled, cold, etc. to maximize the preservation of food nutrition cooking. 2 less salt The daily salt intake of adults should not exceed 6 grams. Eating too salty will make the body's metabolic waste not drain well, and water retention in the body causes edema and obesity. 3 less sugar World Health Organization: The daily sugar intake of adults and children should be controlled under 50 grams, preferably no more than 25 grams. Consumption of large amounts of added sugar will stimulate the rapid rise of insulin levels, thereby accelerating the synthesis of fat, and even trigger the risk of diabetes. 4 bogey taste Heavy flavors ar
阅读全文