Is the Decreased urine volume a sign of kidney failure?

Clinically, many patients with renal failure have symptoms of oliguria, so is it an early sign of kidney failure? What should be paid attention to?
In patients with nephropathy, there are symptoms of oliguria or no anuria, which may be caused by acute renal failure.
Metabolic wastes such as creatinine, urea nitrogen and creatine are mainly excreted in the body.
In general, each person produces 35 grams of nitrogen waste per day, with 15ml of urine diluted per gram of waste. Therefore, the minimum effective urine volume per day should be 500ml.
Is Decreased urine volume a sign of kidney failure?
The higher the protein content, the greater the amount of urine needed to eliminate metabolic waste. When there is less urine, there is too much waste accumulation in the body to produce toxic symptoms.
When being Chronic renal failure, kidneys have been severely damaged. The medication have to be reasonable. If drug cannot smoothly by urine, it also may be poisoning symptoms.
Seventy percent of the drugs used in the clinic are completely or partially excreted. Therefore, changes in renal function are bound to cause changes in kinetics and pharmacodynamics. It is important that patients with renal failure properly regulate the dose.

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