The causes of urinary protein and its harms the kidney cells

First, we need to know how the urinary protein is produced. Usually, the daily urinary protein is no more than 0.15g protein. But how is the urinary protein produced in the kidney patients? There are mainly three aspects:
Inflammation: inflammation caused by immune complex deposition could damage glomerular filtration membrane. Particularly the effacement of podocyte foot leads to lots of protein loss.
2.Internal pressure rise
Both high blood pressure and Diabetes can lead to increased pressure in the kidney, which is mainly caused by elevated blood pressure in the glomeruli, which can also cause urinary protein.
3. Renal tubules were damaged.
The renal tubule is damaged and the reabsorption capacity is affected. Although the glomerular filtration function is completely normal, the renal tubule can not be completely reabsorbed into the blood, which can also cause the loss of protein.
The causes of urinary protein and its harms the kidney cells
Ii. The harm of urinary protein.
There are two main aspects to the damage of persistent leakage proteins:
1. Destroy the filtration barrier.
Proteins are macromolecules, which can damage the glomerular filtration barrier when it leaks, leading to increased damage to the foot cells, which in turn causes more protein to leak out.
2. Cause oedema
A large number of protein loss can result in the reduction of plasma albumin, and the decrease of plasma albumin can cause the imbalance of colloid osmotic pressure, resulting in edema.

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