The main causes of membranous nephropathy
According to the latest pathological study, we found that the production of
membranous nephropathy is related to the anti-phospholipase A2 receptor in the
glomerular foot cells.
Due to sudden infections (like a cold) or other factors that led to the decrease of the immune system, the exposed by the experience, the antibodies attack, which is the resistance to phospholipase A2 receptor antibodies.
The receptor binds to the antibody and becomes an immune complex.
This is located in the glomerular podocytes of immune complex, and will attract complement attack. Two further combinations form the membrane attack complex, gradually lead to cell damage, thickening of basement membrane.
According to the pathological changes of renal units, membranous nephropathy is divided into four stages:
Phase I: the immune complex has just begun to accumulate in the basement membrane, without causing structural changes.
Phase 2: immune complex deposition gradually increased, the basement membrane
began to thicken, nailing process formation.
Stage 3: spike enlargement and fusion.
Stage 4: the immune complex is gradually absorbed, and the nail process is formed in a chain - like change.
The treatment of first and second stage is relatively easy. By the third stage, with the thickening of the basement membrane, the glomerular filtration barrier gradually loses its function, unable to prevent protein leakage, and the treatment becomes more difficult.
Due to sudden infections (like a cold) or other factors that led to the decrease of the immune system, the exposed by the experience, the antibodies attack, which is the resistance to phospholipase A2 receptor antibodies.
The receptor binds to the antibody and becomes an immune complex.
This is located in the glomerular podocytes of immune complex, and will attract complement attack. Two further combinations form the membrane attack complex, gradually lead to cell damage, thickening of basement membrane.
According to the pathological changes of renal units, membranous nephropathy is divided into four stages:
Phase I: the immune complex has just begun to accumulate in the basement membrane, without causing structural changes.
Stage 3: spike enlargement and fusion.
Stage 4: the immune complex is gradually absorbed, and the nail process is formed in a chain - like change.
The treatment of first and second stage is relatively easy. By the third stage, with the thickening of the basement membrane, the glomerular filtration barrier gradually loses its function, unable to prevent protein leakage, and the treatment becomes more difficult.
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